BOS Master Series Monographs (Volume 1) Giant Cell Tumors of Bone

This monograph seeks to summarize the current information and treatment options available for GCT. A lucid description about the imaging modalities available, their interpretation, and how to differentiate GCT from other diagnoses is followed by a description of its pathology. A distinct new driver mutation in the histone gene H3F3A G34W has been identified in over 90% of GCT cases and helps the pathologist confirm diagnosis in challenging cases. The monograph concludes with an algorithm that outlines the various treatment options of GCT and a few case reports highlighting the challenges in managing these tumors. • A detailed description of the current trends in the diagnosis and management of giant cell tumors (GCT) of bone. • Surgery for GCT of bone has been described in detail. This will enable general orthopods to employ these principles and techniques in their practice for management of not only GCT, but also other benign/locally aggressive tumors of bone. • The role of adjuvant therapies such as denosumab, serial embolization, and radiation in the management of GCT of bone has been discussed. • A case series has been provided to highlight decision-making and treatment options for various presentations of GCT of bone.

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