Essentials of Antimicrobial Stewardship, 2/E for Clinical Microbiologists and Infectious Disease Physicians | AMS, Diagnostic Stewardship and Hospital Antibiogram Guide with CLSI and EUCAST Updates

Essentials of Antimicrobial Stewardship, 2nd Edition is a comprehensive working reference on antimicrobial stewardship for the clinical microbiology laboratory and the hospital stewardship team. Structured across 41 chapters in six sections, it moves from the core components of an antimicrobial stewardship (AMS) programme through diagnostic stewardship, the hospital antibiogram, antimicrobial agents, clinical (therapy) stewardship, and AMS in special situations and the One Health approach. The book is built for day-to-day practice. It details how to implement and monitor an AMS programme, run diagnostic stewardship from specimen collection through selective reporting and breakpoint-to-MIC interpretation, build and validate routine and specialized antibiograms, analyse MDR, XDR and PDR phenotypes, and frame empirical, targeted and prophylactic antimicrobial therapy at the level of an individual hospital. Tables, flowcharts and clinical images support each step, and a closing chapter presents puzzles in the rational use of antimicrobial agents. This edition incorporates recent advances across every section. Diagnostic stewardship chapters are updated to the latest CLSI and EUCAST guidance, including revised clinical breakpoints, reporting of fosfomycin, aminoglycosides and CZA-ATM synergy, and susceptibility testing for difficult organisms; the modified Duke's criteria are added; the antibiogram section adds validation based on the general acceptable 5 percent rule; the antimicrobial agents section adds newer beta-lactams and BLBLI, newer aminoglycosides, tetracyclines and quinolones and several novel agents, with a major revision of the tuberculosis chapter; and the targeted-therapy chapters for gram-negative and gram-positive infections have been substantially revised. Who This Book Is For: Clinical microbiologists: running diagnostic stewardship, susceptibility testing, reporting and the hospital antibiogram. Infectious disease physicians: leading antimicrobial stewardship programmes and framing hospital antibiotic policy. Why This Book Helps: Operationalises stewardship: step-by-step implementation, monitoring and intervention strategies for an AMS programme. Connects the laboratory to the bedside: diagnostic stewardship guidance from specimen quality through selective reporting, biomarkers and point-of-care tests. Standardises antibiotic policy: empirical, targeted and prophylactic therapy tables and flowcharts for building an institution-level policy. Keeps interpretation current: aligns susceptibility reading and reporting with the latest CLSI and EUCAST breakpoints and methods. Supports antibiogram work: routine, specialized, syndromic and multifacility antibiograms plus validation and MDR, XDR and PDR analysis. Key Features: 41 chapters across six sections: core AMS components, diagnostic stewardship, hospital antibiogram, antimicrobial agents, clinical stewardship and special situations. Dedicated antibiogram section covering routine, enhanced, syndromic, subtraction and multifacility antibiograms with a validation exercise. Antimicrobial agents section covering PK-PD, mechanism of action, spectrum and resistance, updated with newer beta-lactams, BLBLI, aminoglycosides, tetracyclines, quinolones and novel agents. Targeted therapy chapters for gram-positive and gram-negative infections, plus antifungal stewardship and antimicrobial prophylaxis. Empirical therapy chapter spanning cardiovascular, CNS, intra-abdominal, respiratory, bone and joint, ocular, paediatric and neonatal infections, febrile neutropenia and transplant recipients.

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