National Guidelines on Management and Control of Sickle Cell Disease for Hematologists and Medical Officers | Screening, Hydroxyurea, Transfusion, Gene Therapy and State-Wise Prevalence Data: 1

National Guidelines on Management and Control of Sickle Cell Disease is a national clinical-practice guideline jointly developed by the Indian College of Hematology (ICH, the academic wing of the Indian Society of Hematology & Blood Transfusion, ISHBT) and the Indian Council of Medical Research (ICMR). Rather than a conventional student textbook, it is a professional reference distilling India's current evidence and program experience on sickle cell disease (SCD) into a single, structured resource for the clinicians and program planners who screen for, diagnose, and manage this major public health condition. The guideline runs 20 chapters, opening with the magnitude of the problem and detailed state-wise epidemiology, then moving through screening and diagnosis, clinical presentation, and the full clinical management pathway - stable-condition management, hydroxyurea therapy, iron overload and chelation therapy, vaso-occlusive crisis and acute pain, management of complications, transfusion support, hematopoietic cell transplant and gene therapy, immunization and antibiotic prophylaxis, and ongoing monitoring - before addressing special situations (pregnancy, surgery), newer drugs, food and nutrition, and closing with prevention and control strategy, research priorities, the patient community's own perspective, and a concrete roadmap for SCD care in India. The epidemiology chapter alone compiles district-wise, color-coded prevalence maps and figures for Gujarat, Maharashtra, Rajasthan, Madhya Pradesh, and Odisha, drawn from published literature and program data (including unpublished premarital and newborn screening data), each chapter closing with a boxed summary and a full reference list. Who This Book Is For: Hematologists: a single-source, ICMR/ISHBT-backed reference covering the complete SCD management pathway from diagnosis through hydroxyurea therapy, transfusion support, and hematopoietic cell transplant/gene therapy. Medical Officers: implements national screening and control program guidance directly relevant to district- and PHC-level SCD programs. Public Health Professionals: state-wise epidemiological data and screening-program design guidance for planning coverage in high-burden tribal regions. Pediatricians: newborn and early-childhood screening protocols and pediatric-relevant clinical presentation content, since SCD screening and diagnosis are predominantly pediatric-stage interventions. Policy Makers and Researchers: dedicated chapters on research needs and priorities, the patient community's perspective, and a roadmap for SCD in India support program and policy decisions. Why This Book Helps: Consolidates a fragmented evidence base: brings together published and unpublished screening data, program experience, and clinical protocols into one ICMR/ISHBT/ICH-endorsed reference instead of scattered state-level or institutional guidance. Targets the actual high-burden geography: district-wise prevalence maps for Gujarat, Maharashtra, Rajasthan, Madhya Pradesh, and Odisha let program planners direct screening resources to the districts and tribal communities carrying the highest disease burden. Structures the complete management pathway: from screening and diagnosis through stable-condition care, hydroxyurea therapy, transfusion, and advanced options like hematopoietic cell transplant and gene therapy, in the sequence clinicians actually use. Covers situations general hematology references skip: dedicated chapters on SCD in pregnancy and SCD and surgery address clinical scenarios that carry disease-specific risk and are easy to under-manage without SCD-specific guidance. Connects policy to patient reality: closing chapters on prevention and control strategy, research priorities, and patients' own perspective on their needs give policy makers a rounded basis for program design, not just clinical protocol. Key Features: 20 chapters spanning epidemiology, screening and diagnosis, clinical presentation, and the complete management pathway (stable-condition care, hydroxyurea therapy, iron overload and chelation therapy, vaso-occlusive crisis, complications, transfusion support, hematopoietic cell transplant and gene therapy, immunization and antibiotic prophylaxis, and monitoring). Jointly developed by the Indian College of Hematology (ICH) , the academic wing of the Indian Society of Hematology & Blood Transfusion (ISHBT), together with the Indian Council of Medical Research (ICMR). District-wise, color-coded prevalence maps for Gujarat, Maharashtra, Rajasthan, Madhya Pradesh, and Odisha, compiled from published and unpublished screening-program data. Dedicated chapters on Management of Sickle Cell Disease in Pregnancy and Sickle Cell Disease and Surgery , plus Newer Drugs and Food and Nutrition chapters. Closing chapters on Research Needs, the Sickle Cell Disease Community's own perspective, and a concrete Roadmap for SCD in India , alongside chapter-end summaries and extensive referencing throughout.

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