Pharmaceutical Biotechnology: Concepts and Applications (Misl-Wiley)

Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, the book offers a broad introduction to protein science and recombinant DNA technology, key areas that underpin the whole subject. With two separate chapters devoted to these important topics, students are provided with the basic principles and coverage of how these techniques are applied in the development and production of biopharmaceuticals. Table of Contents: Preface Acronyms Pharmaceuticals, biologics and biopharmaceuticals Introduction to pharmaceutical products Biopharmaceuticals and pharmaceutical biotechnology History of the pharmaceutical industry The age of biopharmaceuticals Biopharmaceuticals: Current status and future prospectsProtein structure Introduction Overview of protein structure Higher level structure Protein stability and folding Protein post-translational modification G ene manipulation and recombinant DNA technology Introduction Nucleic acids: Function and structure Recombinant production of therapeutic proteins Classical gene cloning and identification The drug development process Introduction Discovery of biopharmaceuticals The impact of genomics and related technologies upon drug discovery Gene chips Proteomics Structural genomics Pharmacogenetics Initial product characterization Patenting Delivery of biopharmaceuticals Nasal, trans mucosal and transdermal delivery systems Preclinical studies Pharmacokinetics and pharmacodynamics Toxicity studies The role and remit of regulatory authorities Conclusion Sources and upstream processing Introduction Sources of biopharmaceuticals Upstream processing Downstream processing Introduction Initial product recovery Cell disruption Removal of nucleic acid Initial product concentration Chromatographic purification High-performance liquid chromatography of proteins Purification of recombinant proteins Final product formulation Product analysis Introduction Protein-based contaminants Removal of altered forms of the protein of interest from the product stream Detection of protein-based product impurities Immunological approaches to detection of contaminants Endotoxin and other pyrogenic contaminants The cytokines: The interferon family Cytokines Cytokine receptors Cytokines as biopharmaceuticals The interferon's Interferon biotechnology Conclusion Cytokines: Interleukins and tumour necrosis factor Introduction Interleukin-2 Interleukin-1 Interleukin-11 Tumour necrosis factors Growth factors Introduction Hematopoietic growth factors Growth factors and wound healing Therapeutic hormones Introduction Insulin Glucagon Human growth hormone The gonadotropins Medical and veterinary applications of gonadotropins

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